Journal of Sport Physiology Special Groups
The effect of linear endurance trainings along with the salvia extract supplementation on liver gene expression of some inflammatory markers in male wistar rats
Document Type : Original Article
Authors
1 PhD student in sports physiology, Department of Sports Physiology, Faculty of Educational Sciences and Psychology, Mohaghegh Ardabili University, Ardabil, Iran.
2 Assistant Professor of Sports Physiology, Department of Sports Physiology, Faculty of Educational Sciences and Psychology, Zanjan Islamic Azad University, Zanjan, Iran.
3 Master of Applied Sports Physiology, Department of Sports Physiology, Faculty of Human Sciences, Zanjan University, Zanjan, Iran.
4 Master of Applied Sports Physiology, Department of Sports Physiology, Faculty of Educational Sciences and Psychology, Zanjan Islamic Azad University, Zanjan, Iran.
Abstract
Background: The purpose of this study was to investigate the effect of linear endurance training with salvia extract supplementation on liver TNF-α and CRP gene expression in male rats. Materials and Methods: 34 adult male wistar rats (8 weeks old, weight 204.45±9.08 g) after One week of acclimation, were randomly assigned into 5 groups: control (n=6), liner training (n=8), supplementation (n=6), saline (n=6) and liner training-supplementation (n=8(. The training protocol consisted of running on treadmill for 8 weeks (5 days a week) at 10 m/min for 30 minutes in the first week which gradually increased to reach 35 m/min for 70 min in the last week. Salvia extract was administered (100 mg/kg) by oral gavage technique before each training session. TNF-α and CRP gene expression was performed using Real Time PCR test. Data analysis was performed using ANOVA test (P≤0.05). Results: TNF-α and CRP expression in the liver in the linear training group was a significantly higher than the control group (P =0.0001). Also CRP expression in the liver in the linear training+ salvia group was a significantly lower than the linear group (P =0.0001). also TNF-α expression in the liver in the linear training+ salvia group was a no significantly lower than the linear group (P =0.252). Conclusion: Intense endurance training causes Inflammation effect. In addition to its known effects on pathological studies, salvia extract can be effective in modulating the inflammation caused by intense training with its anti-inflammatory effects.
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