Document Type : Original Article

Authors

• Mostafa Babaeinejad ¹
• Mohammad Tajik ¹
• Ali Hosseinabadi ²

¹ Department of exercise physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

² Department of Physical Education and sport science, University of Tehran, Tehran, Iran

Abstract

Background and purpose: Leukemia inhibitory factor (LIF) is a myokine that is affected by overweight and has inflammatory and destructive effects. Since exercise causes excess weight loss, the aim of this study is the effect of aerobic and resistance exercises on muscle LIF gene expression in rats fed a high-fat diet.

Research method: In this experimental study, 32 rats were randomly divided into four groups: healthy control, obese control, obese + aerobic exercise, and obese + resistance exercise. The training was done for 4 weeks with moderate aerobic intensity (50-65% of VO2max). For resistance training, rats were trained to climb a ladder (height 110 cm, slope 80%, and the distance between the bars of the ladder 2 cm), based on determining the maximum of one repetition. A high-fat diet of 40% fat, 13% protein, and 47% carbohydrate was prepared and continued until the mice reached the obesity threshold. The tissue sample was taken from the gluteus muscle.

Results: The expression of LIF in the obese control group was significantly increased compared to the healthy control group (P=0.039). The expression of LIF in the resistance training group was significantly decreased compared to the obese control group (P=0.046). There was no significant difference between the aerobic exercise group and the obese control group (P=0.059). There was a significant difference between the aerobic and resistance training groups regarding FSTL-1 (P=0.042).

Conclusion: Resistance training seems to have a greater effect on LIF expression in the muscles of obese samples compared to aerobic exercise.

Keywords

• training
• leukemia inhibitory factor
• high-fat diet