Journal of Exercise Physiology in Special Populations

Effect of Aerobic , resistance and combined exercise on lipid profile and vascular disease risk in postmenopausal women

Document Type : Original Article

Authors

1 Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Bojnord, Iran.

2 Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Bojnord, Iran

3 Assistant Professor, Department of Physical Education, Faculty of Humanities, Atrak Quchan University, Iran

Abstract

Purposes:

This study aimed to investigate the effects of 12 weeks of aerobic, resistance, and combined training on lipid profile and cardiovascular disease (CVD) risk factors in postmenopausal women.



Materials and Methods:

Sixty postmenopausal women (aged 50–65 years) were randomly assigned to four groups: aerobic training (n=15), resistance training (n=15), combined training (n=15), and control (n=15). Interventions consisted of 12 weeks of training (3 sessions per week, 60 minutes per session) at moderate to high intensity. Lipid profile (LDL, HDL, triglycerides) and CVD markers (CRP, blood pressure) were measured at baseline and at the end of the study.



Results:

ANCOVA analysis with Tukey's post hoc test showed a significant difference between groups in LDL, indicating that the combined group performed best in all physiological variables and was significantly better than the control group (p=0.001) and one of the aerobic or resistance groups (p=0.001).



Discussion:

The combined group was the most effective intervention with a 15% reduction in LDL and 18% in triglycerides p<0.05, confirming its superiority over the aerobic (10% reduction in LDL) and resistance (12% reduction in triglycerides) groups. These findings emphasize the importance of combined programs. It seems that combining aerobic and resistance training is more effective in postmenopausal women.

Keywords

  1. منابع:

    1. Matthews KA, Crawford SL, Chae CU, Everson-Rose SA, Sowers MF, Sternfeld B, et al. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? journal of the american college of cardiology. 2009;54(25):2366-73.
    2. mendis s, puska p, norrving be. global atlas on cardiovascular disease prevention and control2011.
    3. l woodard j, a sugarman m, a nielson k, carson smith j, seidenberg m, durgerian s, et al. lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging. current alzheimer research. 2012;9(4):436-46.
    4. el khoudary sr, aggarwal b, beckie tm, hodis hn, johnson ae, langer rd, et al. menopause transition and cardiovascular disease risk: implications for timing of early prevention: a scientific statement from the american heart association. circulation. 2020;142(25):e506-e32.
    5. mann s, beedie c, jimenez a. differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. sports medicine. 2014;44(2):211-21.
    6. wang y, xu d. effects of aerobic exercise on lipids and lipoproteins. lipids in health and disease. 2017;16(1):132.
    7. cornelissen va, smart na. exercise training for blood pressure: a systematic review and meta‐analysis. journal of the american heart association. 2013;2(1):e004473.
    8. kodama s, tanaka s, saito k, shu m, sone y, onitake f, et al. effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. archives of internal medicine. 2007;167(10):999-1008.
    9. strasser b, siebert u, schobersberger w. resistance training in the treatment of the metabolic syndrome: a systematic review and meta-analysis of the effect of resistance training on metabolic clustering in patients with abnormal glucose metabolism. sports medicine. 2010;40(5):397-415.
    10. bea jw, cussler ec, going sb, blew rm, metcalfe ll, lohman tg. resistance training predicts six-year body composition change in postmenopausal women. medicine and science in sports and exercise. 2010;42(7):1286.
    11. donges c, duffield r, drinkwater e. effects of resistance or aerobic exercise training on interleukin-6, c-reactive protein, and body composition. medicine and science in sports and exercise. 2010;42(2):304-13.
    12. ho ss, dhaliwal ss, hills ap, pal s. effects of chronic exercise training on inflammatory markers in australian overweight and obese individuals in a randomized controlled trial. inflammation. 2013;36(3):625-32.
    13. akhlaghi m, kohanmoo a. sleep deprivation in development of obesity, effects on appetite regulation, energy metabolism, and dietary choices. nutrition research reviews. 2023:1-21.[ In Persian]
    14. krušnauskas r. effects of gender, age and physical fitness on responsiveness to interval training: lietuvos sporto universitetas.; 2021.
    15. koh j-h, hancock cr, terada s, higashida k, holloszy jo, han d-h. pparβ is essential for maintaining normal levels of pgc-1α and mitochondria and for the increase in muscle mitochondria induced by exercise. cell metabolism. 2017;25(5):1176-85. e5.
    16. schjerve ie, tyldum ga, tjønna ae, stølen t, loennechen jp, hansen he, et al. both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. clinical science. 2008;115(9):283-93.
    17. sardeli av, tomeleri cm, cyrino es, fernhall b, cavaglieri cr, chacon-mikahil mpt. effect of resistance training on inflammatory markers of older adults: a meta-analysis. experimental gerontology. 2018;111:188-96.
    18. o’brien mw. the impact of exercise training on pulse wave velocity in healthy and clinical populations: a 1 systematic review of systematic reviews 2.
    19. roeters van lennep je, westerveld ht, erkelens dw, van der wall ee. risk factors for coronary heart disease: implications of gender. cardiovascular research. 2002;53(3):538-49.
    20. xin c, ye m, zhang q, he h. effect of exercise on vascular function and blood lipids in postmenopausal women: a systematic review and network meta-analysis. international journal of environmental research and public health. 2022;19(19):12074.
    21. curtis cl, goldberg a, kleim ja, wolf sl. translating genomic advances to physical therapist practice: a closer look at the nature and nurture of common diseases. physical therapy. 2016;96(4):570-80.
    22. dibben go, faulkner j, oldridge n, rees k, thompson dr, zwisler a-d, et al. exercise-based cardiac rehabilitation for coronary heart disease: a meta-analysis. european heart journal. 2023;44(6):452-69.
    23. sarzynski ma, davidsen pk, sung yj, hesselink mk, schrauwen p, rice tk, et al. genomic and transcriptomic predictors of triglyceride response to regular exercise. british journal of sports medicine. 2015;49(23):1524-31.
    24. cheng c-c, hsu c-y, liu j-f. effects of dietary and exercise intervention on weight loss and body composition in obese postmenopausal women: a systematic review and meta-analysis. menopause. 2018;25(7):772-82.
    25. carvalheira-dos-santos r, delgado r-m, ferreira-dos-santos g, vaz-carneiro a. analysis of the cochrane review: exercise-based cardiac rehabilitation for coronary heart disease. cochrane database syst rev. 2016; 1: cd001800. acta medica portuguesa. 2019;32(7-8):483-7.
    26. meta-análise urse, fuerza l. effects of combined training on body composition, muscle strength and aerobic power in women: a systematic review and meta-analysis. rev bras med esporte. 2025;31:e2022_0389.
Journal of Exercise Physiology in Special Populations
Volume 2, Issue 3
September 2026
Pages 1-14