Document Type : Original Article

Authors

• rahil atashgahian
• majid kashef
• mojtaba salehpour
• arezoo eskandari shahrabi

Shahid Rajaee Teacher Training University, Tehran

Abstract

Purpose:
Myocardial inflammation is an effective factor in the development of diabetic cardiomyopathy, which increases the risk of mortality in patients. The aim of the present study was to investigate the effect of moderate-intensity aerobic training on reducing cardiac tissue inflammation in male diabetic Wistar rats..
Materials and Methods:
18 male Wistar rats weighing (180±20) grams were divided into 3 groups: healthy control (6 rats), diabetic control (6 rats), and diabetic with aerobic training (6 rats). Moderate-intensity aerobic training was performed by running on a treadmill with zero incline for 6 weeks, 5 days a week. NF-κB protein levels were measured by Western blotting. For statistical data analysis, paired t-test, one-way analysis of variance, and Tukey's post hoc test were used at P≤0.05 level using SPSS22 software.
Results:
The results showed that six weeks of moderate-intensity aerobic training resulted in a significant decrease in fasting blood sugar in the diabetic group with training from (131±377) to (81±249) mg/dL (P=0.017). This decrease was not observed in the other two groups. The level of NF-κB protein in the aerobic training group (1.18±0.007) was significantly reduced compared to the diabetic control group (1.88±0.09) (P ≤0.001) and its values were close to the healthy group.
Conclusion
Aerobic exercise reduced fasting blood glucose and NF-κB protein levels in male diabetic Wistar rats. These results suggest that aerobic training may be a promising non-pharmacological approach to diabetes management by modulating cardiac inflammatory signaling and improving blood glucose control.


Keywords:
Cardiomyopathy, aerobic training, hyperglycemia, NF-κB

Keywords

• Cardiomyopathy
• aerobic training
• hyperglycemia
• NF-κB